ral GTP-Binding Proteins - PMC

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Select item 57273301.

Ral signaling pathway in health and cancer

Adel Rezaei Moghadam, Elham Patrad, Elham Tafsiri, Warner Peng, Benjamin Fangman, Timothy J Pluard, Anthony Accurso, Michael Salacz, Kushal Shah, Brandon Ricke, Danse Bi, Kyle Kimura, Leland Graves, Marzieh Khajoie Najad, Roya Dolatkhah, Zohreh Sanaat, Mina Yazdi, Naeimeh Tavakolinia, Mohammad Mazani, Mojtaba Amani, Saeid Ghavami, Robyn Gartell, Colleen Reilly, Zaid Naima, Tuba Esfandyari, Faris Farassati

Cancer Med. 2017 Dec; 6(12): 2998–3013. Published online 2017 Oct 18. doi: 10.1002/cam4.1105

PMCID:: PMC5727330

Article PDF–378K

Select item 91392442.

The RAL Enigma: Distinct Roles of RALA and RALB in Cancer

Dillon S. Richardson, Jonathan M. Spehar, David T. Han, Prathik A. Chakravarthy, Steven T. Sizemore

Cells. 2022 May; 11(10): 1645. Published online 2022 May 14. doi: 10.3390/cells11101645

PMCID:: PMC9139244

Article PDF–1.5M

Select item 79490493.

Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases

Catherine A. Hurd, Paul Brear, Jefferson Revell, Sarah Ross, Helen R. Mott, Darerca Owen

J Biol Chem. 2021 Jan-Jun; 296: 100101. Published online 2020 Nov 23. doi: 10.1074/jbc.RA120.015735

PMCID:: PMC7949049

Article PDF–4.0M

Select item 82777114.

Parallel Rap1>RalGEF>Ral and Ras signals sculpt the C. elegans nervous system

Jacob I. Mardick, Neal R. Rasmussen, Bruce Wightman, David J. Reiner

Dev Biol. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: Dev Biol. 2021 Sep; 477: 37–48. Published online 2021 May 13. doi: 10.1016/j.ydbio.2021.05.004

PMCID:: PMC8277711

Article PDF–1.4M

Select item 57126315.

RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer

Chao Yan, Dan Theodorescu

Pharmacol Rev. 2018 Jan; 70(1): 1–11. Published online 2018 Jan. doi: 10.1124/pr.117.014415

PMCID:: PMC5712631

Article PDF–652K

Select item 73438386.

κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis

Stephanie Beel, Lina Kolloch, Lisa H. Apken, Lara Jürgens, Andrea Bolle, Nadine Sudhof, Sankar Ghosh, Eva Wardelmann, Michael Meisterernst, Konrad Steinestel, Andrea Oeckinghaus

Nat Commun. 2020; 11: 3409. Published online 2020 Jul 8. doi: 10.1038/s41467-020-17226-0

PMCID:: PMC7343838

Article PDF–4.7M

Select item 64848527.

Ral Signals through a MAP4 Kinase-p38 MAP Kinase Cascade in C. elegans Cell Fate Patterning

Hanna Shin, Rebecca E.W. Kaplan, Tam Duong, Razan Fakieh, David J. Reiner

Cell Rep. Author manuscript; available in PMC 2019 Apr 26.

Published in final edited form as: Cell Rep. 2018 Sep 4; 24(10): 2669–2681.e5. doi: 10.1016/j.celrep.2018.08.011

PMCID:: PMC6484852

Article PDF–952K

Select item 71323018.

Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases

Khuchtumur Bum-Erdene, Degang Liu, Giovanni Gonzalez-Gutierrez, Mona K. Ghozayel, David Xu, Samy O. Meroueh

Proc Natl Acad Sci U S A. 2020 Mar 31; 117(13): 7131–7139. Published online 2020 Mar 16. doi: 10.1073/pnas.1913654117

PMCID:: PMC7132301

Article PDF–1.8M

Select item 82167199.

RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

Máté Nászai, Karen Bellec, Yachuan Yu, Alvaro Román-Fernández, Emma Sandilands, Joel Johansson, Andrew D Campbell, Jim C Norman, Owen J Sansom, David M Bryant, Julia B Cordero

eLife. 2021; 10: e63807. Published online 2021 Jun 7. doi: 10.7554/eLife.63807

PMCID:: PMC8216719

Article PDF–7.7M

Select item 500007910.

Inhibition of Ral GTPases Using a Stapled Peptide Approach

Jemima C. Thomas, Jonathan M. Cooper, Natasha S. Clayton, Chensu Wang, Michael A. White, Chris Abell, Darerca Owen, Helen R. Mott

J Biol Chem. 2016 Aug 26; 291(35): 18310–18325. Published online 2016 Jun 22. doi: 10.1074/jbc.M116.720243

PMCID:: PMC5000079

Article PDF–2.4M

Select item 456625511.

Divergent Roles of CAAX Motif-signaled Posttranslational Modifications in the Regulation and Subcellular Localization of Ral GTPases

Leanna R. Gentry, Akiyuki Nishimura, Adrienne D. Cox, Timothy D. Martin, Denis Tsygankov, Motohiro Nishida, Timothy C. Elston, Channing J. Der

J Biol Chem. 2015 Sep 11; 290(37): 22851–22861. Published online 2015 Jul 27. doi: 10.1074/jbc.M115.656710

PMCID:: PMC4566255

Article PDF–1.8M

Select item 835390912.

Ral GTPase–activating protein regulates the malignancy of pancreatic ductal adenocarcinoma

Shingo Yoshimachi, Ryutaro Shirakawa, Mingxin Cao, Duc Anh Trinh, Pan Gao, Natsumi Sakata, Kento Miyazaki, Kota Goto, Takayuki Miura, Kyohei Ariake, Shimpei Maeda, Kunihiro Masuda, Masaharu Ishida, Hideo Ohtsuka, Michiaki Unno, Hisanori Horiuchi

Cancer Sci. 2021 Aug; 112(8): 3064–3073. Published online 2021 Jun 15. doi: 10.1111/cas.14970

PMCID:: PMC8353909

Article PDF–2.3M

Select item 660581313.

Ral GTPases in Schwann cells promote radial axonal sorting in the peripheral nervous system

Andrea Ommer, Gianluca Figlia, Jorge A. Pereira, Anna Lena Datwyler, Joanne Gerber, Jonathan DeGeer, Giovanna Lalli, Ueli Suter

J Cell Biol. 2019 Jul 1; 218(7): 2350–2369. Published online 2019 Jun 14. doi: 10.1083/jcb.201811150

PMCID:: PMC6605813

Article PDF–4.5M

Select item 755662814.

RAL GTPases mediate multiple myeloma cell survival and are activated independently of oncogenic RAS

Marcel Seibold, Thorsten Stühmer, Nadine Kremer, Anja Mottok, Claus-Jürgen Scholz, Andreas Schlosser, Ellen Leich, Ulrike Holzgrabe, Daniela Brünnert, Santiago Barrio, K. Martin Kortüm, Antonio G. Solimando, Manik Chatterjee, Hermann Einsele, Andreas Rosenwald, Ralf C. Bargou, Torsten Steinbrunn

Haematologica. 2020 Sep 1; 105(9): 2316–2326. Published online 2019 Oct 10. doi: 10.3324/haematol.2019.223024

PMCID:: PMC7556628

Article PDF–1.8M

Select item 8701815.

Activation of the Ral and Phosphatidylinositol 3′ Kinase Signaling Pathways by the Ras-Related Protein TC21

Marta Rosário, Hugh F. Paterson, Christopher J. Marshall

Mol Cell Biol. 2001 Jun; 21(11): 3750–3762. doi: 10.1128/MCB.21.11.3750-3762.2001

PMCID:: PMC87018

Article PDF–1.6M

Select item 601141916.

dSTIM- and Ral/Exocyst-Mediated Synaptic Release from Pupal Dopaminergic Neurons Sustains Drosophila Flight

Shlesha Richhariya, Siddharth Jayakumar, Sanjay Kumar Sukumar, Gaiti Hasan

eNeuro. 2018 May-Jun; 5(3): ENEURO.0455-17.2018. Prepublished online 2018 May 22. Published online 2018 Jun 18. doi: 10.1523/ENEURO.0455-17.2018

PMCID:: PMC6011419

Article PDF–2.7M

Select item 653433817.

Developmental fidelity is imposed by genetically separable RalGEF activities that mediate opposing signals

Hanna Shin, Christian Braendle, Kimberly B. Monahan, Rebecca E. W. Kaplan, Tanya P. Zand, Francisca Sefakor Mote, Eldon C. Peters, David J. Reiner

PLoS Genet. 2019 May; 15(5): e1008056. Published online 2019 May 14. doi: 10.1371/journal.pgen.1008056

PMCID:: PMC6534338

Article PDF–3.1M

Select item 2537318.

The Small GTP-binding Protein R-Ras Can Influence Integrin Activation by Antagonizing a Ras/Raf-initiated Integrin Suppression Pathway

Tariq Sethi, Mark H. Ginsberg, Julian Downward, Paul E. Hughes

Mol Biol Cell. 1999 Jun; 10(6): 1799–1809. doi: 10.1091/mbc.10.6.1799

PMCID:: PMC25373

Article PDF–375K

Select item 497380619.

Ral-Arf6 crosstalk regulates Ral dependent exocyst trafficking and anchorage independent growth signalling

Archana Pawar, Jeremy A. Meier, Anwesha Dasgupta, Neha Diwanji, Neha Deshpande, Kritika Saxena, Natasha Buwa, Siddhi Inchanalkar, Martin Alexander Schwartz, Nagaraj Balasubramanian

Cell Signal. 2016 Sep; 28(9): 1225–1236. doi: 10.1016/j.cellsig.2016.05.023

PMCID:: PMC4973806

Article PDF–1.6M

Select item 622628820.

RalB directly triggers invasion downstream Ras by mobilizing the Wave complex

Giulia Zago, Irina Veith, Manish Kumar Singh, Laetitia Fuhrmann, Simon De Beco, Amanda Remorino, Saori Takaoka, Marjorie Palmeri, Frédérique Berger, Nathalie Brandon, Ahmed El Marjou, Anne Vincent-Salomon, Jacques Camonis, Mathieu Coppey, Maria Carla Parrini

eLife. 2018; 7: e40474. Published online 2018 Oct 15. doi: 10.7554/eLife.40474